Pre-referral rectal artesunate is no “magic bullet” in weak health systems

Severe malaria is a potentially fatal condition that requires urgent treatment. In a clinical trial, a sub-group of children treated with rectal artesunate (RAS) before being referred to a health facility had an increased chance of survival. We recently published in BMC Medicine results of the CARAMAL Project that did not fnd the same protective efect of prereferral RAS implemented at scale under real-world conditions in three African countries. Instead, CARAMAL identifed serious health system shortfalls that impacted the entire continuum of care, constraining the efectiveness of RAS. 

Correspondence to the article criticized the observational study design and the alleged interpretation and consequences of our fndings. Here, we clarify that we do not dispute the life-saving potential of RAS, and discuss the methodological criticism. We acknowledge the potential for confounding in observational studies. Nevertheless, the totality of CARAMAL evidence is in full support of our conclusion that the conditions under which RAS can be benefcial were not met in our settings, as children often failed to complete referral and post-referral treatment was inadequate.

The criticism did not appear to acknowledge the realities of highly malarious settings documented in detail in the CARAMAL project. Suggesting that trial-demonstrated efcacy is sufcient to warrant large-scale deployment of prereferral RAS ignores the paramount importance of functioning health systems for its delivery, for completing postreferral treatment, and for achieving complete cure. Presenting RAS as a “magic bullet” distracts from the most urgent priority: fxing health systems so they can provide a functioning continuum of care and save the lives of sick children.
The data underlying our publication is freely accessible on Zenodo