At Risk of Plasmodium Falciparum Malaria

• If treatment of an uncomplicated attack of malaria caused by these parasites is delayed
• Second and third trimesters of pregnancy
• Patients with HIV/AIDS
• People who have undergone splenectomy

High-transmission areas

• Young children
• Visitors (of any age) from non-endemic areas

Transmission areas defined

• High transmission: hyperendemic or holoendemic area where the prevalence is over 50% most of the year among children aged 2–9 years
• Moderate transmission area: mesoendemic area where the prevalence is 11–50% during most of the year among children aged 2–9 years
• Low transmission area: hypoendemic area where the prevalence is 10% or less during most of the year among children aged 2–9 years